Sergej M. Ostojic1

1University of Novi Sad, Faculty of Sport and Physical Education, Serbia; University of Belgrade, School of Medicine, Belgrade, Serbia

Performance-enhancing effects of dietary nucleotides: do mitochondria play a role?

Monten. J. Sports Sci. Med. 2015, 4(2), 35-36


Nucleotides are group of natural biomonomeric molecules and novel dietary supplements with performance-enhancing attributes. However, their mechanisms of action and target biological structures are poorly understood and identified. This short paper overviews the possible role of mitochondria during the utilization of nucleotides for exercise performance. Mitochondria-related effects of nucleotides have been identified, along with obstacles for dietary nucleotides delivery to the organelle.


Nucleotides, Mitochondria, Exercise performance, Bioenergetics, DNA repair

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Arnaud, A., López-Pedrosa, J.M., Torres, M.I., & Gil, A. (2003). Dietary nucleotides modulate mitochondrial function of intestinal mucosa in weanling rats with chronic diarrhea. J Pediatr Gastroenterol Nutr., 37(2), 124-131.

Bacha, U., Nasir, M., Ali, M.A., Muhammad, J., & Sheikh, A.A. (2013). Nucleotides supplementation improves various function of the body. J Anim Health Prod., 1(1), 1–5

Bangsbo, J., Johansen, L., Quistorff, B., & Saltin, B. (1993). NMR and analytic biochemical evaluation of CrP and nucleotides in the human calf during muscle contraction. J Appl Physiol., 74(4), 2034-2039.

Carver, J.D., & Walker, W.A.. (1995). The role of nucleotides in human nutrition. J Nutr Bioche., 6(2):58–72.

Gutiérrez-Castrellón, P., Mora-Magaña, I., Díaz-García, L., Jiménez-Gutiérrez, C., Ramirez-Mayans, J., & Solomon-Santibáñez, G.A. (2007). Immune response to nucleotide-supplemented infant formulae: systematic review and meta-analysis. Br J Nutr., 98(Suppl1), S64-67.

Jafari, A., Hosseinpourfaizi, M.A., Houshmand, M., & Ravasi, A.A. (2005). Effect of aerobic exercise training on mtDNA deletion in soleus muscle of trained and untrained Wistar rats. Br J Sports Med., 39(8), 517-520.

Kaasik, A., Veksler, V., Boehm, E., Novotova, M., Minajeva, A., & Ventura-Clapier, R. (2001). Energetic crosstalk between organelles: architectural integration of energy production and utilization. Circ Res., 89(2), 153-159.

Klingenberg, M. (2008). The ADP and ATP transport in mitochondria and its carrier. Biochim Biophys Acta., 1778(10), 1978-2021.

McNaughton, L., Bentley, D., & Koeppel, P. (2007). The effects of a nucleotide supplement on the immune and metabolic response to short term, high intensity exercise performance in trained male subjects. J Sports Med Phys Fitness., 47(1), 112-118.

McNaughton, L., Bentley, D.J., & Koeppel, P. (2006). The effects of a nucleotide supplement on salivary IgA and cortisol after moderate endurance exercise. J Sports Med Phys Fitness., 46(1), 84-89.

Ostojic, S.M., Idrizovic, K., & Stojanovic, M.D. (2013). Sublingual nucleotides prolong run time to exhaustion in young physically active men. Nutrients, 5(11), 4776-4785.

Ostojic, S.M., & Obrenovic, M. (2012). Sublingual nucleotides and immune response to exercise. Journal of the International Society of Sports Nutrition, 9(1), 31.

Pérez, M.J., Sánchez-Medina. F., Torres. M., Gil, A., & Suárez, A. (2004). Dietary nucleotides enhance the liver redox state and protein synthesis in cirrhotic rats. J Nutr., 134(10), 2504-2508.

Riera, J., Pons, V., Martinez-Puig, D., Chetrit, C., Tur, J.A., Pons, A., & Drobnic, F. (2013). Dietary nucleotide improves markers of immune response to strenuous exercise under a cold environment. J Int Soc Sports Nutr., 10(1), 20.

Van Buren, C.T., Kulkarni, A.D., & Rudolph, F.B. (1994). The role of nucleotides in adult nutrition. J Nutr., 124(1 Suppl), 160S-164S.

Willis, W.T., & Jackman, M.R. (1994). Mitochondrial function during heavy exercise. Med Sci Sports Exerc., 26(11), 1347-1353.